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KMID : 0624620120450010044
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BMB Reports
2012 Volume.45 No. 1 p.44 ~ p.46
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BioSMACK: a linux live CD for genome-wide association analyses
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Hong Chang-Bum
Kim Young-Jin
Moon Sang-Hoon
Shin Young-Ah
Go Min-Jin
Lee Jong-Young
Cho Yoon-Shin
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Abstract
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Recent advances in high-throughput genotyping technologies have enabled us to conduct a genome-wide association study (GWAS) on a large cohort. However, analyzing millions of single nucleotide polymorphisms (SNPs) is still a difficult task for researchers conducting a GWAS. Several difficulties such as compatibilities and dependencies are often encountered by researchers using analytical tools, during the installation of software. This is a huge obstacle to any research institute without computing facilities and specialists. Therefore, a proper research environment is an urgent need for researchers working on GWAS. We developed BioSMACK to provide a research environment for GWAS that requires no configuration and is easy to use. BioSMACK is based on the Ubuntu Live CD that offers a complete Linux-based operating system environment without installation. Moreover, we provide users with a GWAS manual consisting of a series of guidelines for GWAS and useful examples. BioSMACK is freely available at http://ksnp.cdc. go.kr/biosmack.
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KEYWORD
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GWAS, Human genome, Linux, Live CD, SNP
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